Crestor, Lipitor, Zocor or - Which statin is right for you?
A diagnosis of high cholesterol can be intimidating, but there's a lot you can do to control this condition. In addition to changing your diet and upping your exercise, the addition of an inhibitor of HMG-CoA reductase inhibitors - a class of drugs commonly called "statins" - safely and effectively lower your cholesterol. (HMG-CoA reductase allows our liver cholesterol products, when the chemical is inhibited, the amount of cholesterol is reduced accordingly.) For people with heart disease, statins may reduce the risk of an event heart failure and death. If you and your doctor have determined that you need a statin, how can you take statins to suit your needs?
There are six statins on the market: atorvastatin, fluvastatin, lovastatin, pravastatin, rosuvastatin and simvastatin. They differ in their ability to reduce cholesterol, and they are also distinguished by their rate of reduction of heart attacks. Costs are also very different - and since most people taking statins for a long time, the costs add up over the years. With all these variables, the choice of statin good for you can be complex.
All statins can lower LDL ("bad") cholesterol and triglycerides, and raise HDL ("good") cholesterol. Statins differ in how much they can do, and it is highly dependent on the dose. Drug Digest says:
If the need to reduce LDL-C is 35-36%, a statin should be acceptable choices for therapy. For a desired reduction in LDL-C greater than 42%, simvastatin (Zocor), atorvastatin (Lipitor) or rosuvastatin (Crestor) is required.
Indeed, statins are the best known Crestor, Lipitor and Zocor (probably because they have the greatest effect on cholesterol). The latter two are also approved by Consumer Reports. Gather evidence on the effectiveness, safety and cost into account, the publication notes that these two statins. " Consumer Reports Best Buy Drugs "They recommend:
• Generic simvastatin (20 mg or 40 mg) - if you need 30% or greater reduction of LDL and / or have heart disease or diabetes, or if you have had a heart attack or acute coronary syndrome and your LDL is not very high.
• Atorvastatin (Lipitor) (40 mg or 80 mg) - if you have had a heart attack or acute coronary syndrome and your LDL is high, use for two years, then reconfirm or need to go to simvastatin generic.
Graphics drug Digest few great comparisons. For example, they show that Lipitor (10-80 mg.) May reduce total cholesterol by 25-45%, while Zocor (5-80 mg.) Can reduce the same numbers from 19 to 36%, and Crestor ( 5-40 mg). can reduce it by 33-46%. As for lowering HDL, Lipitor can offer reduced 5-9%, Zocor decreases HDL 8-16%, and reduces the numbers Crestor by 8-14%. As you can see, the choice of appropriate statin has a lot to do with what numbers (total cholesterol, HDL, LDL, triglycerides) you are trying to effect.
A final consideration is that last year there were reports on an observational study conducted by Pfizer which suggested that there were some advantages to the use of Lipitor Crestor. However, keep in mind that Pfizer conducted the study, and they are the manufacturer of Lipitor, and defend this drug compared to the product of Merck Zocor, which is now available in a generic form. Here is the information as presented by the Wall Street Journal:
An analysis published in the latest Journal of Clinical Therapeutics, from a large database of medical records and found that patients taking Lipitor had a 12% lower risk of a cardiovascular event than those on simvastatin, the generic name Zocor. Patients on Lipitor had a 15% lower risk of having a heart attack.
The so-called observational studies like this one that focus on the data after the facts are not as powerful as prospective clinical trials. Jack Tu, a cardiologist specializing in the research results at the Canadian Institute for Clinical Evaluative Sciences, Pfizer said the latest study did not take into account factors that may predispose a patient to heart problems, such as rates smoking and cholesterol. "Just this reason alone, you would not recommend that everyone should switch to Lipitor," he said.
However, Pfizer hopes that doctors will take note. "We made two fairly large observational studies and patients have a lower risk of cardiovascular events in Lipitor [versus] simvastatin," says Susan Shiff, Team Leader of Pfizer cardiovascular outcomes. "Physicians should take this into account in discussions with patients." aejpum
You really should talk to your doctor about statin is right for you. In general, the best plan is to take the lowest dose of a statin that leads you to your target for cholesterol. Too high doses can be harmful to your liver and muscles. If you experience muscle pain and pain when taking a statin, contact your doctor immediately.